abstract：:1. For the past decade, using radioligand binding, contractility and immunohistochemical techniques, we have been characterizing vascular smooth muscle (VSM) adrenoceptors in four functionally different canine blood vessels, namely the dog aorta (DAO), dog mesenteric artery (DMA), dog mesenteric vein (DMV) and dog sap...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwan DC

更新日期：1999-10-01 00:00:00

abstract：:1. NBPA is a derivative of 3-n-butylpathalide isolated from Apium granolens Linn. 2. At concentrations ranging from 6 x 10(-6) to 10(-6) mol/L, NBPA inhibited the L-type calcium current in guinea-pig myocardial cells and cultured human neuroblastoma cells. 3. At 10(-6) mol/L, NBPA markedly inhibited calcium-dependent ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang J,Peng X,Wei G,Su D

更新日期：1999-10-01 00:00:00

abstract：:1. The clinical observation that hypertension is more common in males and postmenopausal women than in premenopausal women suggests vascular protective effects of female sex hormones, including hormone-mediated inhibition of vascular tone. The purpose of the present study was to investigate whether the Ca2+ mobilizati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Crews JK,Khalil RA

更新日期：1999-09-01 00:00:00

abstract：:1. The functional innervation of autonomic target tissues occurs early during development, at a time when both the nerves and post-synaptic target tissues are still differentiating. 2. Physiological responses appear soon after the arrival of the first fibres when uptake and release mechanisms within the nerves are alr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hill CE,Phillips JK,Sandow SL

更新日期：1999-08-01 00:00:00

abstract：:1. It has previously been shown that perfusion with high O2-affinity-erythrocytes decreases venous PO2 (PVO2) and decreases O2 uptake (VO2) in contracting muscle at the same O2 delivery (arterial O2 concentration x flow). A linear VO2-PVO2 relationship has been obtained with a VO2-axis intercept, suggesting that, duri...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki H,Misawa H,Kishi T,Ohga Y,Sakata S,Takaki M

更新日期：1999-08-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:1. Although it is well established that hypertension is the main risk factor for stroke, the complexity of cerebrovascular problems related to hypertension is not generally appreciated. 2. Hypertension can cause stroke through many mechanisms. A high intraluminal pressure will lead to extensive alteration in endotheli...

journal_title：Clinical and experimental pharmacology & physiology

authors： Johansson BB

更新日期：1999-07-01 00:00:00

abstract：:1. Treatment with heparin has beneficial effects in diabetic nephropathy. The occurrence of increased urinary albumin excretion in diabetic patients reflects general vascular dysfunction, including increased transcapillary permeability of macromolecules. The aim of the present study was to evaluate the effects of hepa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oturai PS

更新日期：1999-05-01 00:00:00

abstract：:1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

更新日期：1999-05-01 00:00:00

abstract：:1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park HY,Nabika T,Notsu Y,Kobayashi S,Masuda J

更新日期：1999-04-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-04-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:1. L-Type Ca2+ channels play important roles in cardiac excitation and conduction. The present study used the whole-cell patch-clamp technique to investigate properties of Ca2+ channels in guinea-pig isolated ventricular myocytes. The effects of internal application of the proteolytic enzymes trypsin and carboxypeptid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dooley PC,Hancox JC,Chapman RA

更新日期：1999-02-01 00:00:00

abstract：:1. Within the lung, endothelin (ET)-1 is synthesized and released by airway epithelial and vascular endothelial cells, as well as by inflammatory cells, such as macrophages. Following release, ET-1 can modulate the activities of a wide range of different cell types within the lung through the stimulation of specific e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Henry PJ

更新日期：1999-02-01 00:00:00

abstract：:1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

更新日期：1999-01-01 00:00:00

abstract：:1. There is controversy regarding plasma catecholamine levels in patients with hypertrophic cardiomyopathy (HCM) and few data exist on serial plasma catecholamine measurements during exercise. The present study determined whether cardiovascular and plasma catecholamine responses to exercise were altered in patients wi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Omodani H,Kinugawa T,Ogino K,Furuse Y,Yamaguchi M,Mori M,Endo A,Kato M,Kato T,Osaki S,Miyakoda H,Igawa O,Hisatome I,Shigemasa C

更新日期：1998-12-01 00:00:00

abstract：:1. The use of non-linear dynamic analysis for the measurement of control processes in low-dimensional signals, for example, blood pressure and heart rate variability, are well established and accepted. However, the application of these analytical techniques to a high-dimensional signal, such as renal sympathetic nerve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang T,Johns EJ

更新日期：1998-11-01 00:00:00

abstract：:1. Raised intracranial pressure (ICP) is a major factor associated with morbidity and mortality in patients with severe head injury. Identifying the mechanisms responsible for raised ICP may be difficult and, as a result, treatment prescribed may be non-specific and often ineffective. 2. Research aimed at obtaining mo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lewis SB

更新日期：1998-11-01 00:00:00

abstract：:1. The aim of the present study was to determine the effects of prolonged prostaglandin E2 (PGE2) administration on the function of the foetal kidneys and lungs in order to gain a greater understanding of the role played by PGE2 in the control of foetal fluid balance. By studying the effects of PGE2 at two gestational...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wlodek ME,Hooper SB,Thorburn GD,Tester ML,Harding R

更新日期：1998-10-01 00:00:00

abstract：:1. The present brief review examines some of the new developments in the area of circadian rhythm research. 2. The discovery of the mouse clock and m-per genes and their similarity to other clock genes like per and tim has provided new insight into the control of rhythms in vertebrates. In mice, these genes are expres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kennaway DJ

更新日期：1998-10-01 00:00:00

abstract：:1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gude NM,King RG,Brennecke SP

更新日期：1998-09-01 00:00:00

abstract：:1. Studies of evolutionary temperature adaptation of muscle and locomotor performance in fish are reviewed with a focus on the Antarctic fauna living at subzero temperatures. 2. Only limited data are available to compare the sustained and burst swimming kinematics and performance of Antarctic, temperate and tropical s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Franklin CE

更新日期：1998-09-01 00:00:00

abstract：:1. To determine whether total interruption of the local cardiac renin-angiotensin system by angiotensin II (AngII) receptor antagonist limits myocardial ischaemia, intracoronary (i.c.) or intravenous (i.v.) infusion of AngII receptor antagonists was compared in ischaemic dogs. 2. Dogs subjected to 90 min coronary arte...

journal_title：Clinical and experimental pharmacology & physiology

authors： So T,Nakashima Y,Imamura M,Arakawa K

更新日期：1998-07-01 00:00:00

abstract：:1. The concentration of renin and angiotensinogen (Ao) and the activity of angiotensin I-converting enzyme (ACE) was measured in the ascites fluid of nephrotic rats obtained 8 days after puromycin aminonucleoside (PAN) injection. 2. Ascites fluid, serum and urine proteins of these rats were analysed by sodium dodecyl ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cruz C,Correa-Rotter R,Mézquita C,Medina-Campos ON,Pedraza-Chaverrí J

更新日期：1998-07-01 00:00:00

abstract：:1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study, this treatment produced a significant...

journal_title：Clinical and experimental pharmacology & physiology

authors： van den Buuse M,Wilks DP,Cornish JL

更新日期：1998-07-01 00:00:00

abstract：:1. Effects of FR139317, an endothelin ETA receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of NG-nitro-L-arginine (NOARG), the NO synthase inhibitor, at a rate of 40 micrograms/kg per min, prod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Matsumura Y,Kuro T,Hashimoto N,Taira S

更新日期：1998-06-01 00:00:00

abstract：:1. The aim of the present study was to determine the brain sites mediating aspects of respiratory and cardiovascular control in adult humans using non-invasive functional magnetic resonance (fMRI) procedures, thereby avoiding the spatial and temporal sampling limitations associated with classic neural assessment techn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Harper RM,Gozal D,Bandler R,Spriggs D,Lee J,Alger J

更新日期：1998-06-01 00:00:00

abstract：:1. The effect of propofol on cardiac whole-cell sodium currents and single sodium channels in rat isolated ventricular myocytes was examined using patch-clamp techniques. 2. Propofol caused a block of the whole-cell sodium current, the potency of block depending on the holding potential. When cells were held at -90 mV...

journal_title：Clinical and experimental pharmacology & physiology

authors： Saint DA,Tang Y

更新日期：1998-05-01 00:00:00

abstract：:1. The present study was designed to compare and contrast the effects of 1 year's treatment with angiotensin-converting enzyme inhibition (captopril 25-100 mg daily) and beta-blockade (atenolol 50-100 mg daily) on hypertensive cardiac structure and function as well as the other established cardiovascular risk factors ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laufer E,Reid C,Qi XL,Jennings GL

更新日期：1998-03-01 00:00:00

abstract：:1. Glucuronidation is the major route of metabolism of dihydrocodeine (DHC) and accounts for 25-30% of an oral dose in urine. The kinetics of DHC-6-glucuronide formation in liver microsomes from five human donors and the effect of a number of potential inhibitor drugs were examined using a newly developed and validate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kirkwood LC,Nation RL,Somogyi AA

更新日期：1998-03-01 00:00:00

abstract：:1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Binko J,Murphy TV,Majewski H

更新日期：1998-02-01 00:00:00

abstract：:1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

更新日期：1998-02-01 00:00:00

abstract：:1. The transplacental transfer of D-xylose was investigated in the present study. 2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound. 3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subseq...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staud F,Fendrich Z,Karlícek R,Pávek P

更新日期：1998-01-01 00:00:00

abstract：:1. We tested the hypothesis that the pattern and the intensity of autonomic mechanisms causing vasoconstriction in the resting bronchial circulation of awake dogs also exists in awake sheep. It was also postulated that sighing behaviour and the associated bronchovascular dilatation induced by non-adrenergic, non-choli...

journal_title：Clinical and experimental pharmacology & physiology

authors： McIlveen S,White S,Parsons G

更新日期：1997-12-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

更新日期：1997-11-01 00:00:00

abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

journal_title：Clinical and experimental pharmacology & physiology

authors： Waller J,Siney L,Hoult JR,Brain SD

更新日期：1997-11-01 00:00:00

abstract：:1. It has been suggested that astrocytes prompt the induction of blood-brain barrier (BBB) functions in cerebrovascular endothelial cells. 2. In the present study we have tried to elucidate the genetic differences between astrocytes isolated from Wistar-Kyoto (WKY) control rats and astrocytes isolated from stroke-pron...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamagata K,Tagami M,Nara Y,Fujino H,Kubota A,Numano F,Kato T,Yamori Y

更新日期：1997-09-01 00:00:00

abstract：:1. While it is believed that the mammalian distal nephron is not involved in uric acid transport, this has not been directly evaluated. Nevertheless, some studies are consistent with significant distal nephron transport. 2. As uric acid transport in man may be similar to the rat, undirectional uric acid permeability w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ray C,Carney S,Morgan T

更新日期：1997-09-01 00:00:00

abstract：:1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

更新日期：1997-09-01 00:00:00